Tuesday, May 24, 2011

New Study Finds Drug that Limits Spread of Mesothelioma Cells

A new study that will be published this month has found a drug that was originally developed to treat kidney cancer may also prove effective in limiting the spread of mesothelioma in patients as well.

The research, which was conducted by the Institute of Cancer Research at the Medical University of Vienna and published in the May issue of the Journal of Thoracic Oncology, found that temsirolimus - the kinase inhibitor - was able to slow the growth of malignant pleural mesothelioma cells in patients.

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The drug’s ability to do this was linked to it being able to block mTOR-mediated signals, which in turn stopped the growth of the cells. The drug was originally designed to slow tumor growth and treat kidney cancer and renal cell carcinoma.

Even more interesting was the study’s revelation that the drug was able to limit the growth of cells that had been resistant to treatment by cisplastin - a drug commonly used in mesothelioma chemotherapy treatments.

"In our preclinical study, published in the

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